The first cases of smallpox have already been identified in Wales and Northern Ireland.
There has been an outbreak of the rare virus worldwide, with 19 countries confirming infections and new cases bringing the UK to a total of around 80.
It is spread through the United Kingdom through community transmission, and infections are detected daily.
The virus, which is commonly reported in Central and West African countries, causes rash and fever, but the symptoms are mild for most people.
Read more: What are the symptoms of monkeypox and how to catch it?
Dr Giri Shankar, Director of Public Health for Wales, said: “Public health in Wales today (Thursday, 26 May) confirms that a case of monkeypox has been identified in Wales.
“We are working with the UK Health Security Agency (UKHSA), Public Health in Scotland and the Public Health Agency in Northern Ireland and we are ready to respond to cases of monkeypox in Wales.
“The case is being handled appropriately. To protect the patient’s privacy, no more details about the patient will be revealed.”
He added: “We assure people that smallpox is not usually easily spread among humans and the overall risk to the general public is low.
“It’s usually a mild self-limiting disease and most people recover within a few weeks. However, severe illness can occur in some people.”
Health officials in Northern Ireland are expected to hold a briefing later, after the first case has been identified.
Read more: What we know about the largest outbreak of monkeypox in the UK
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14:32 Monkeypox: Answer your questions
The risk to the UK population “remains low”
The number of confirmed cases in the UK is expected to rise later on Thursday when UKHSA updates its data.
Despite the increase, UKHSA said the risk to the entire UK population “remains low”.
Gays and bisexual men and men who have sex with men are urged to be especially aware of the symptoms, especially if they have recently had a new sexual partner.
UKHSA teams monitor the contacts of those with a confirmed case and advise those at highest risk to be isolated for 21 days.
The smallpox vaccine is also available in close contact to reduce the risk of symptoms and severe illness.
Anyone who has concerns that they may be infected with monkeypox is advised to contact NHS 111.
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